Epigenetic regulation of the calcitonin gene–related peptide gene in trigeminal glia
نویسندگان
چکیده
منابع مشابه
Calcitonin Gene-Related Peptide Promotes Peripheral and Central Trigeminal Sensitization
Temporomandibular joint disorder is characterized by peripheral and central sensitization of trigeminal nociceptive neurons. Although CGRP is implicated in the development of central sensitization by stimulating glial activation via its receptor, the mechanism by which CGRP promotes and maintains sensitization of trigeminal nociceptive neurons is not well understood. The goal of my study was to...
متن کاملCalcitonin gene-related peptide promotes cellular changes in trigeminal neurons and glia implicated in peripheral and central sensitization
BACKGROUND Calcitonin gene-related peptide (CGRP), a neuropeptide released from trigeminal nerves, is implicated in the underlying pathology of temporomandibular joint disorder (TMD). Elevated levels of CGRP in the joint capsule correlate with inflammation and pain. CGRP mediates neurogenic inflammation in peripheral tissues by increasing blood flow, recruiting immune cells, and activating sens...
متن کاملThe effect of hypothyroidism on the trigeminal calcitonin gene-related peptide containing motoneurons: an immunohisto-chemical study in late neonatal life
CGRP, which coexists with acetylcholine in trigeminal motoneurons, could be one of the regulatory anterograde factors responsible for the enhanced expression of AChR subunits in neuromuscular junction. It has been also shown that low level of thyroid hormone plasma concentration has influence on the transitional development of muscle fibers and related motoneurons through a sever reduction in A...
متن کاملThe effect of hypothyroidism on the trigeminal calcitonin gene-related peptide containing motoneurons: an immunohisto-chemical study in late neonatal life
CGRP, which coexists with acetylcholine in trigeminal motoneurons, could be one of the regulatory anterograde factors responsible for the enhanced expression of AChR subunits in neuromuscular junction. It has been also shown that low level of thyroid hormone plasma concentration has influence on the transitional development of muscle fibers and related motoneurons through a sever reduction in A...
متن کاملCalcitonin gene-related peptide receptors in rat trigeminal ganglion do not control spinal trigeminal activity.
Calcitonin gene-related peptide (CGRP) is regarded as a key mediator in the generation of primary headaches. CGRP receptor antagonists reduce migraine pain in clinical trials and spinal trigeminal activity in animal experiments. The site of CGRP receptor inhibition causing these effects is debated. Activation and inhibition of CGRP receptors in the trigeminal ganglion may influence the activity...
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ژورنال
عنوان ژورنال: Cephalalgia
سال: 2011
ISSN: 0333-1024,1468-2982
DOI: 10.1177/0333102410391487